Osteochondral scaffold is a structural graded device that used in the repair of large osteochondral defects. In vivo, differing regional load-induced signals will likely alter the physical environment that an osteochondral scaffold provides to support cells, and its effect on the regional cellular response.
Using the osteochondral region as an example, this project is to study the regional cellular responses to localized physical signal changes within a biomimetic environment, and how regional physical environment and mechanical stimuli contribute to the differentiation of mesenchymal stem cells (MSCs) to give a bone and cartilage structure that has distinct cell and ECM hierarchy.
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Jordan, C. M., M. C. Quaye, et al. (2013). "The biomechanical analysis of the TRUFIT bone plug." The Bone & Joint Journal 95B(Supp 12): 22.