Study the regional cellular responses of mesenchymal stem cells to local physical environment in osteochondral scaffold

Abstract

Osteochondral scaffold is a structural graded device that used in the repair of large osteochondral defects. In vivo, differing regional load-induced signals will likely alter the physical environment that an osteochondral scaffold provides to support cells, and its effect on the regional cellular response.

Using the osteochondral region as an example, this project is to study the regional cellular responses to localized physical signal changes within a biomimetic environment, and how regional physical environment and mechanical stimuli contribute to the differentiation of mesenchymal stem cells (MSCs) to give a bone and cartilage structure that has distinct cell and ECM hierarchy.

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References:
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Dormer, N. H., M. Singh, et al. (2010). "Ostenchondral interface tissue engineering using macroscopic gradients of bioactive signals." Annals of Biomedical Engineering 38(6): 2167-2182.

[2]

Wei, H.-W., S.-S. Sun, et al. (2005). "The influence of mechanical properties of subchondral plate, femoral head and neck on dynamic stress distribution of the articular cartilage." Medical Engineering & Physics 27(4): 295-304

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Bailey, A. J., J. P. Mansell, et al. (2004). "Biochemical and mechanical properties of subchondral bone in osteoarthritis." Biorheology 41(3-4): 349-358.

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Biological Areas:

Cell Biology
Biotechnology

BBSRC Area:

Molecules, cells and industrial biotechnology