Identifying novel genetic networks functionally important for healthy ageing of neurons and synapses

Abstract

The global population is living for longer periods, and so we are facing an enormous economical and social burden as our ageing population develops cognitive and neurodegenerative problems. Indeed, age is the primary risk factor for many dementias, but mechanisms connecting ageing and impaired cognition are not well understood. The goal of this project is to identify novel genetic pathways that preserve synaptic function in ageing mice. To achieve this goal the student will use an interdisciplinary approach combining electrophysiology and genomics. This work will allow us to understand novel mechanisms that preserve healthy synaptic function in old age.

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References:
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Biological Areas:

Neurobiology
Ageing

BBSRC Area:

Animal disease, health and welfare