The post-natal development of the hippocampal place cell network

Abstract

’Place cells’ are neurons in the rodent hippocampal formation (HF) which fire only when an animal visits a restricted location in its environment. Recent studies have mapped out the developmental timeline for place cells, showing that they initially emerge early in development, but continue to mature for several weeks thereafter. The aim of this project is to understand how the place cell network is wired up during development, using a combined electrophysiology/network modeling approach, with a particular emphasis on the role of HF neurons that respond to the location of the boundaries of the environment (Boundary-Vector Cells, or ‘BVCs’).

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Biological Areas:

Neurobiology
Development

BBSRC Area:

Genes, development and STEM approaches to biology