The post-natal development of the grid cell continuous attractor network

Abstract

Grid cells are neurons in the Entorhinal cortex of the rat whose firing is tuned to the position of the animal with multiple firing fields , laid out across the environment in a regular hexagonal lattice. Theoretical models have proposed a 2-dimensional continuous attractor as the network architecture underlying grid cell firing. However, how such a network could be wired up during development remains unknown. This project will use a combination of electrophysiological recording and neural network modeling to discover what are the network mechanisms underlying grid cell development.

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References:
[1]

Burak Y, Fiete IR. (2009) Accurate path integration in continuous attractor network models of grid cells. PLoS Comput Biol. Feb;5(2)

[2]

Hafting T1, Fyhn M, Molden S, Moser MB, Moser EI. (2005) Microstructure of a spatial map in the entorhinal cortex. Nature. 11;436(7052).

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McNaughton BL, Battaglia FP, Jensen O, Moser EI, Moser MB. (2006). Path integration and the neural basis of the 'cognitive map'. Nat Rev Neurosci. Aug;7(8):663-78.

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Wills TJ, Cacucci F, Burgess N, O'Keefe J. (2010) Development of the hippocampal cognitive map in preweanling rats. Science Jun 18;328(5985):1573-6.

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Yoon K, Buice MA, Barry C, Hayman R, Burgess N, Fiete IR. (2013) Specific evidence of low-dimensional continuous attractor dynamics in grid cells. Nat Neurosci. Aug;16(8):1077-84.


Biological Areas:

Neurobiology
Development

BBSRC Area:

Genes, development and STEM approaches to biology