Role of the neuronal motor protein KIF21B in neuronal development and connectivity

Abstract

Kinesins are a superfamily of microtubule-based nanomotors that use their ATPase activity to produce force. A number of different kinesins perform essential functions in the nervous system. Nerve cells exhibit a highly polarised and compartmentalised structure including axon and somatodendritic compartment. This polarity is critical for neuronal development, function, signalling and information processing. The mechanisms that underpin the development of neuronal polarity and the polarised targeting of cargo within neurons however remain poorly understood. This project proposes to investigate the role of a poorly characterised brain specific kinesin motor protein (KIF21B) for neuronal polarity and connectivity.

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Biological Areas:

Cell Biology
Neurobiology

BBSRC Area:

Genes, development and STEM approaches to biology
Molecules, cells and industrial biotechnology