The emergence of pathogens resistant to multiple drugs is rapidly becoming one of the most pressing challenges public health. While the urgency of tackling the problem is widely recognised, we still only have a relatively poor understanding of the finer details of the dynamics behind the acquisition of multiple drug resistances. A better description of the underlying processes is needed to allow designing novel mitigation strategies. This work will take advantage of deep high-throughput sequencing and computational modelling to describe and understand the emergence of rapid multidrug resistance in bacteria.
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