Within host variation and emergence of drug resistance mutations

Abstract

The emergence of pathogens resistant to multiple drugs is rapidly becoming one of the most pressing challenges public health. While the urgency of tackling the problem is widely recognised, we still only have a relatively poor understanding of the finer details of the dynamics behind the acquisition of multiple drug resistances. A better description of the underlying processes is needed to allow designing novel mitigation strategies. This work will take advantage of deep high-throughput sequencing and computational modelling to describe and understand the emergence of rapid multidrug resistance in bacteria.

 

ject details are protected. Please login with a valid account to view them.





References:
[1]

Ford CB et al. (2013) Mycobacterium tuberculosis mutation rate estimates from different lineages predict substantial differences in the emergence of drug-resistant tuberculosis. Nat Genet 45:784–90.

[2]

Srivastava S, Pasipanodya JG, Meek C, Leff R, Gumbo T (2011) Multidrug-resistant tuberculosis not due to noncompliance but to between-patient pharmacokinetic variability. J Infect Dis 204:1951–9.

[3]

Gagneux S et al. (2006) The competitive cost of antibiotic resistance in Mycobacterium tuberculosis. Science 312:1944–6

[4]

Walker TM et al. (2013) Whole-genome sequencing to delineate Mycobacterium tuberculosis outbreaks: a retrospective observational study. Lancet Infect Dis 13:137–46.

[5]

Morris RP et al. (2005) Ancestral antibiotic resistance in Mycobacterium tuberculosis. Proc Natl Acad Sci U S A 102:12200–5.


Biological Areas:

Microbiology
Evolution

BBSRC Area:

Animal disease, health and welfare