Unravelling the role of conformational mobility in IgE antibodies on its function in allergies

Abstract

Allergic responses are mediated by immunoglobulin E (IgE) antibodies. IgE contains an extra domain pair at its hinge joining its Fab and Fc regions; its significance is not fully understood. The allergic response involves complexes between IgE and its high and low affinity receptors FcεRI and FcεRII. The PhD project will identify the role of the Fab regions in IgE-receptor complexes. Conformational studies in a broad range of solution conditions will locate the Fab regions of IgE relative to the Fc region. The outcome will help decipher its biological mechanism and is relevant to the >$30 billion antibody biotechnology industry.

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References:
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Biological Areas:

Immunology
Structural Biology

BBSRC Area:

Molecules, cells and industrial biotechnology