Cholesteatoma is a destructive and expanding growth consisting of keratinizing squamous epithelium in the middle ear, which can lead to ossicular damage, invasion of the brain and death. Surgery to remove the cholesteatoma invariably leads to conductive hearing loss and the creation of a “mastoid cavity” that is prone to reinfection (20-80% cases). This project investigates a tissue engineering approach (using a degradable polycaprolactone – bioactive glass scaffold) that, following cholesteatoma removal, aims to (1) regenerate the mastoid bone and (2) prevent re-infection by restoring the integrity of the tympanic cavity/ear canal by regenerating the epithelial membrane surrounding these structures.
L. Nayyer; M. Birchall; A. M Seifalian; G. Jell. Design and development of nanocomposite scaffolds for auricular reconstruction. 2014, Nanomed: Nanotech, Biol and Med: 10 (1): 235-246
Sedaghati T, G. Jell, A. M Seifalian; Investigation of Schwann cell behaviour on RGD-functionalised bioabsorbable nanocomposite for peripheral nerve regeneration. 2014. N Biotechnol. 3;31(3):203-213.
Azevedo M., G. Jell, M. O’Donnell, R. Hill and M.M. Stevens. Characterisation of hypoxia pathway regulating bioactive glasses. 2010, Journal of Materials Chemistry, 20: 8854-8864
Gentleman E., R. J. Swain, N.D. Evans, G. Jell, M. Ball, S. Boonrungsiman, A. Porter, and M. M. Stevens. Comparative material differences revealed in engineered bone as a function of cell specific differentiation. 2009, Nature Materials, 8: 763-70.
Qureshi A A, N D. Padgham and D. Jiang. Day-case major ear surgery: is it viable?. 2006, J. Laryngology and Otology, 120: 168