REACH: Regeneration of the Ear canal And mastoid cavity following CHolesteatoma surgery

Abstract

Cholesteatoma is a destructive and expanding growth consisting of keratinizing squamous epithelium in the middle ear, which can lead to ossicular damage, invasion of the brain and death. Surgery to remove the cholesteatoma invariably leads to conductive hearing loss and the creation of a “mastoid cavity” that is prone to reinfection (20-80% cases). This project investigates a tissue engineering approach (using a degradable polycaprolactone – bioactive glass scaffold) that, following cholesteatoma removal, aims to (1) regenerate the mastoid bone and (2) prevent re-infection by restoring the integrity of the tympanic cavity/ear canal by regenerating the epithelial membrane surrounding these structures.

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References:
[1]

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Biological Areas:

Cell Biology

BBSRC Area:

Genes, development and STEM approaches to biology
Molecules, cells and industrial biotechnology