Dual imaging of nanographene oxide in cells in vitro by Raman and multiphoton bioluminescence microscopy

Abstract

In the last few years, the field of nanobiotechnology has been revolutionised by the emergence of a variety of novel nanomaterials such as graphene, the single atom thick carbon sheet, which attracted attention in the area of biomedicine. A number of staining-free non-destructive microscopy techniques have become available to non-invasively image graphene nanocarriers in biological samples with sub-cellular resolution.  The main goal of this research proposal is to develop a dual imaging platform based on Raman spectroscopy and multiphoton bioluminescence to gain understanding on interactions of nanographene with phagocytic cells which constitute the first defense line of our immune system. 

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Biological Areas:

Cell Biology
Biotechnology

BBSRC Area:

Molecules, cells and industrial biotechnology