Structural and Functional investigations of LARP6, and its role in degenerative muscle disorders


LARP6 is a recently discovered RNA-binding protein involved in regulation of collagen production and muscle differentiation, although little is known about its molecular mechanism(s) of action or its in vivo RNA targets.
The aim of this project is to investigate how LARP6 regulates gene expression at post- transcriptional level during muscle development by using a combination of biophysical, cellular and genetic techniques.

Since aberrant muscle development and collagen production could be linked to neuromuscular disorders and collagen-related diseases, this study will contribute to elucidate any role of LARP6 in degenerative muscle pathologies. 

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Biological Areas:

Structural Biology


Genes, development and STEM approaches to biology
Molecules, cells and industrial biotechnology