Systems microscopy of the biomechanics of cardiac myocytes

Abstract

Force is known to play an important role in the structure and development of cardiac myocytes; however, the exact nature of this role, and the way in which is acts as a signal, are poorly understood.  In this project controlled amounts of force will be applied to single cells to systematically probe the changes that take place.  By using cells from heart failure models we will investigate the different responses in pathological and healthy models.

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References:
[1]

Gautel M. The sarcomeric cytoskeleton: Who picks up the strain? Curr. Opin. Cell Biol. 23 39-46 (2011)

[2]

Cox et al, Nature Methods 9 195-200 (2012)


Biological Areas:

Cell Biology
Biotechnology

BBSRC Area:

Molecules, cells and industrial biotechnology