New data approaches to investigate the effects of age on human immune responses

Abstract

The immune system is a carefully balanced complex system essential to maintenance of health.  The ability of an older person to mount an effective immune response is diminished.  Not only do they have increased infectious disease and poor response to vaccine, but many other age-related diseases are affected by a dysregulated immune system, including cancer, Alzheimer’s disease, cardiovascular disease.

We will integrate high throughput sequencing analysis of B cell/Antibody repertoire with state of the art bioinformatical analysis to identify where age-related failures in humoral immunity occur.  We will create Web tools that will significantly advance the study of immune repertoires.

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References:
[1]

Wu Y-CB, Kipling D and Dunn-Walters DK (2012) Age-related changes in human peripheral blood IGH repertoire following vaccination. Front. Immun. 3:193.

[2]

Gibson KL, Wu Y-C, Barnett Y, Duggan O, Vaughan R, Kondeatis E, Nilsson B-O, Wikby A, Kipling D & Dunn-Walters DK (2009) B cell diversity decreases in old age and is correlated with poor health status. Ageing Cell 8:18-25

[3]

Alexander Ademokun, Yu-Chang Wu, Victoria Martin, Rajive Mitra, Ulrich Sack, Helen Baxendale, David Kipling, Deborah K. Dunn-Walters Vaccination-induced changes in human B cell repertoire and pneumococcal IgM and IgA antibody at different ages. Aging Cell. 2011 Dec;10(6):922-30

[4]

Yu-Chang Wu, David Kipling, Victoria Martin, Alexander A Ademokun, Deborah K Dunn-Walters. (2010) High throughput immunoglobulin repertoire analysis distinguishes between human IgM memory and switched memory B cell populations. Blood 2010 116: 1070-1078. 

[5]

Yu-Chang Wu, David Kipling, Deborah K Dunn-Walters. 2011 The relationship between CD27 negative and positive B cell populations in human peripheral blood. 2011. Frontiers Immunology 2:81.


Biological Areas:

Immunology
Ageing

BBSRC Area:

Animal disease, health and welfare