Understanding of the mechanisms regulating the function and structure of the glomerular filtration barrier

Abstract

Our laboratory has been focusing on the physiology and pathophysiology of blood vessels.

Our research has a specific interest on glomerular capillaries, known to be an extremely specialised vascular district regulated by a specific growth factor network that interconnect the function of perivascular and intravascular cells. Our current work has identified novel molecules and pathways involved in the physiology and pathophysiology of renal and vascular diseases. Our team utilises different in vitro, in vivo, and ex vivo, tools that has allowed us to answer novel and interesting questions and to be at the forefront of research in our field.

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References:
[1]

1)              Dessapt-Baradez C, Woolf AS, White KE, Pan J, Huang JL,Hayward A, Price KL, Kolatsi-Joannou M, Locatelli M, Diennet M, Webster Z, Smillie SJ, Nair V, Kretzler M, Cohen CD, Long DA, Gnudi L. Targeted glomerular angiopoietin-1 therapy for early diabetic kidney disease. J Am Soc Nephrol. 2014 Jan;25(1):33-42.

[2]

1)              Long DA, Kolatsi-Joannou M, Price KL, Dessapt-Baradez C, Huang JL, Papakrivopoulou E, Hubank M, Korstanje R, Gnudi L, Woolf AS. Albuminuria is associated with too few glomeruli and too much testosterone. Kidney Int. 2013 Feb 27. doi: 10.1038/ki.2013.45. [Epub ahead of print]  

[3]

1)              Dessapt C, Karalliedde J, Hernandez-Fuentes M, Prieto Martin P, Maltese G, Dettani N, Atkar R, Viberti GC, Gnudi L. Circulating Vascular Progenitor Cells in patients with Type 1 Diabetes and Microalbuminuria. Diabetes Care, 33(4):875-877, 2010.

[4]

Ku CH, White KE, Dei Cas A, Hayward A, Webster Z, Bilous R, Marshall SM, Viberti GC, and Gnudi L. Inducible overexpression of sFlt-1 in podocytes ameliorates glomerulopathy in diabetic mice. Diabetes, 57: 2824 -2833, 2008.

[5]

Long DA, Price KL, Ioffe E, Gannon CM, Gnudi L, White KE, Yancopoulos GD, Rudge JS, Woolf AS. Angiopoietin-1 therapy enhances fibrosis and inflammation following folic acid-induced acute renal injury. Kidney Int. 74(3):300-9. 2008.  


Biological Areas:

Cell Biology
Physiology

BBSRC Area:

Animal disease, health and welfare