Systems biology approach to aging-associated cardiac disease: From molecular imaging to whole-heart computational modelling

Abstract

The project aims to explore aging-related structural and functional changes in the heart and dissect their role in the genesis of twin cardiovascular epidemics of atrial fibrillation (AF) and heart failure (HF). Molecule-to-cell and tissue level changes associated with aging will be quantified using molecular imaging techniques. Such structural changes will then be linked with changes of the electrical function in the twin AF/HF condition via biophysically detailed 3D computational modelling of the heart. Model predictions will be used to design therapies aimed at counteracting the effects of aging, and hence preventing the disease.

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References:
[1]

Svetlichnaya J, Klein L. Atrial fibrillation in elderly patients with heart failure: convergence of two cardiovascular epidemics in the 21st Century. Expert Review of Cardiovascular Therapy 9 (2011), 903-912.

[2]

Abd Allah ESH, Aslanidi OV, Tellez JO, Zhang H, Dobrzynski H, Boyett MR. Postnatal development of transmural gradients in expression of ion channels and Ca2+-handling proteins in the ventricle. Journal of Molecular & Cellular Cardiology 53 (2012), 145-155.

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Aslanidi OV, Colman MA, Stott J, Dobrzynski H, Boyett MR, Holden AV, Zhang H. 3D virtual human atria: A computational platform for studying clinical atrial fibrillation. Progress in Biophysics & Molecular Biology 107 (2011), 156-168.

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Benson AP, Aslanidi OV, Zhang H, Holden AV. The canine virtual ventricular wall: a platform for dissecting pharmacological effects on propagation and arrhythmogenesis. Progress in Biophysics & Molecular Biology 96 (2008), 187-208.


Biological Areas:

Cell Biology
Ageing

BBSRC Area:

Genes, development and STEM approaches to biology