The functional capabilities of the mammalian central nervous system depend on the formation of precise neuronal connections established during development. In mammals, the multiple processes coordinating the assembly of these intricate circuits contain a certain level of plasticity. These properties bring to the system a significant degree of flexibility, which is fundamental for the formation and maintenance of complex biological systems. The aims of this project are to investigate the dynamic cellular mechanisms that underlie the formation of connectivity, which brings sensory information to the brain, through the use of a unique mammalian genetic model with perturbed visual system development.
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