Unravelling the interaction between zinc a2 glycoprotein, zinc and b adrenergic receptor – a potential new pathway for fat metabolism.

Abstract

The National Obesity Forum predicts that half of all adults will be obese by 2050. Zinc a2 glycoprotein (ZAG) is an adipokine that breaks down human fat cells (lipolysis). The biochemical mechanism underlying this effect is unknown. This project will use novel computational and biophysical methods based on peptides and lipids to identify the molecular mechanism of ZAG-induced lipolysis to answer a major and long standing research question. The student will benefit from unique cross-disciplinary training opportunities at the forefront of ZAG research. Potentially, cost-saving solutions to the NHS in combatting the effects of obesity will be uncovered.

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References:
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Biological Areas:

Structural Biology

BBSRC Area:

Molecules, cells and industrial biotechnology