Coupling between alternative promoters and alternative splicing in different types of neurons.

Abstract

Most of the genes that are expressed in neuron-specific manner have extremely long introns, such that the total gene length often exceeds 100kb. It is not clear why these genes need to be so long. We recently discovered a new mechanism controlling the expression of long genes, which links the choice of alternative promoters to alternative splicing, enabling a greater diversity of alternative isoforms to be produced in different regions of the brain. Here, a combination of computational, genomic, genetic and cell biology will be used to examine the role of this mechanism for the differentiation of different neuronal types.

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Biological Areas:

Neurobiology
Genetics

BBSRC Area:

Genes, development and STEM approaches to biology